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Thursday, April 23, 2020 | History

2 edition of Pulmonary macrophage and epithelial cells found in the catalog.

Pulmonary macrophage and epithelial cells

Pulmonary macrophage and epithelial cells

Proceedings of the Sixteenth Annual Hanford Biology Symposium at Richland, Washington, September 27-29, 1976 (ERDA symposium series ; 43)

by

  • 154 Want to read
  • 22 Currently reading

Published by For sale by the National Technical Information Service .
Written in English

    Subjects:
  • Epithelial cells,
  • Lungs,
  • Macrophages,
  • Congresses

  • The Physical Object
    FormatUnknown Binding
    Number of Pages618
    ID Numbers
    Open LibraryOL8345284M
    ISBN 100870792040
    ISBN 109780870792045

    Macrophages are ubiquitously present innate immune cells in humans and animals belonging to both invertebrates and vertebrates. These cells were first recognized by Elia Metchnikoff in in the larvae of starfish upon insertion of thorns of tangerine tree and later in Daphnia magna or common water flea infected with fungal spores as cells responsible for the process of phagocytosis of Cited by: 2. In particular the pro-apoptotic effects of ceramide were suspected as events in the lung destruction that occurs as a result of apoptotic loss of structural cells comprising the alveolar walls, such as microvascular endothelial cells and alveolar epithelial by: the air space from the pulmonary capillary. An inflamma-tory response, with edema and perhaps subsequent fibrosis, lipids) secreted by the epithelial cells of the lung [48]. Newly gates are taken up by both the epithelial cell and the alveolar macrophage [49]; most of those taken up by the epithelial.


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Pulmonary macrophage and epithelial cells Download PDF EPUB FB2

The relevance of this secretory function of the macrophage to the pathogenesis of destructive diseases of the lung such as emphysema remains to be determined. Full text Get a printable copy (PDF file) of the complete article (M), or click on a page image below to browse page by by: In pulmonary fibrosis the initial disease process is diverse (Table ) and may cause changes in either type I or type II alveolar epithelial cells, pulmonary macrophages, neutrophils or T-lymphocytes.

Interactions between these cells produce numerous cytokines, which amplify the inflammatory response and initiate cellular repair mechanisms. Although changes in macrophage phenotypes have been observed in a variety of advanced lung diseases (12, 13), understanding the role of these cells in regulating disease phenotypes has been limited due in part to the lack of specific markers.

The authors and their colleagues provide researchers an invaluable tool to begin targeted approaches to Cited by: 4. @article{osti_, title = {Pulmonary macrophage and epithelial cells}, author = {Sanders, C L and Schneider, R P and Dagle, G E and Ragan, H A}, abstractNote = {Separate abstracts were prepared for the 41 papers presented at the conference.

Abstracts of two papers have appeared in previous issues of Energy Research Abstracts. Secreted products of lung epithelial cells.

The conducting airways of the lungs, from the trachea to terminal bronchioles, are formed by budding and branching of endoderm-derived tubules by the process of branching morphogenesis human lungs, cartilaginous airways extend deep into the lung parenchyma and are surrounded by an abundance of submucosal glands that secrete fluids, Cited by: Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome Lisa R.

Young, 1,2,3 Peter M. Gulleman, 1 Chelsi W. Short, 1 Harikrishna Tanjore, 2 Taylor Sherrill, 2 Aidong Qi, 1 Andrew P. McBride, 1 Rinat Zaynagetdinov, 2 John T.

Benjamin, 4 William E. Lawson, 2 Sergey V. Novitskiy, 2 and Timothy S Cited by:   Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue.

Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate the Cited by: Get this from a library.

Pulmonary macrophage and epithelial cells: proceedings of the Sixteenth Annual Hanford Biology Symposium at Richland, Washington, September[Charles L Sanders; United States. Energy Research and Development Administration.

Division of Biomedical and Environmental Research.; Pacific Northwest Laboratory.;]. An alveolar macrophage (or dust cell) is a type of macrophage, a professional phagocyte, found in the pulmonary alveoli, near the pneumocytes, but separated from the wall.

Activity of the alveolar macrophage is relatively high, because they are located at one of the major boundaries between the body and the outside world. Publisher Summary. This chapter examines the definitions, similarities and differences between asthma and chronic obstructive pulmonary disease (COPD), drawing heavily on the latest information on asthma and COPD that is included in the guidelines on the diagnosis and management of these diseases from two widely respected global initiatives, the Global Initiative for Asthma (GINA) and the.

Pulmonary fibrosis is a chronic and progressive interstitial lung disease of known and unknown etiology. Over the past decades, macrophages have been recognized to play a significant role in IPF. A pulmonary alveolus (plural: alveoli, from Latin alveolus, "little cavity") is a hollow cup-shaped cavity found in the lung parenchyma where gas exchange takes place.

Lung alveoli are found in the acini at the beginning of the respiratory are located sparsely on the respiratory bronchioles, line the walls of the alveolar ducts, and are more numerous in the blind-ended alveolar on: Lung.

High-mobility group box-1 protein (HMGB1) expressed and released from tubular epithelial cells and interstitial macrophages was essential for the M1 macrophage : Zhilong Jiang.

Surrounding intestinal epithelial cells release TGF-β, which induces the change from proinflammatory macrophage to noninflammatory macrophage. [90] Even though the inflammatory response is downregulated in intestinal macrophages, phagocytosis is still carried on: Phagocytosis.

A rounded or cuboidal epithelial stem cell found in the bottom layer of pseudostratified epithelia, such as the epidermis and the lining of the airways of the lung.

Either of two types of cell found in the bottom layer of the olfactory epithelium; one type is a flattened "basal cell proper", and the other is a rounded stem cell called a. Pulmonary macrophage influx and activation is also mediated by leukotriene B 4 (LTB 4), a lipid mediator produced by multiple cells in the lung.

Macrophage-derived LTB 4 promotes endothelial injury and pulmonary artery (PA) smooth muscle cell (SMC) proliferation in PAH patients and rat models of Cited by: 7.

Studies from our laboratory have shown that human alveolar macrophages (AM) and bronchial epithelial cells (HBEC) exposed to ambient particles (PM10) in vitro increase their production of inflammatory mediators and that supernatants from PMexposed cells shorten the transit time of monocytes through the bone marrow and promote their release into the by:   Reported herein are the results of an interpretative synthesis review of the literature assessing the inflammatory response of lung macrophages (MΦ) and epithelial cells to tobacco smoke as measured ex vivo.

Papers were retrieved using Boolean operations from PubMed and by:   Interactions between alveolar macrophages (AMs) and epithelial cells may promote inflammatory responses to air pollution particles.

Normal rat AMs, the alveolar type II epithelial cell line RLE-6TN (RLE), or cocultures of both cell types were incubated with various particles (0–50 μ g/ml) for 24 h, followed by assay of released TNF- α and MIPCited by: Mission Statement: A major focus of the research at the Pulmonary Center focuses on epithelial cell and molecular biology.

This focus relates to the central role that the pulmonary epithelium plays in normal lung function, and to the fact that a key element of lung diseases is dysregulation of. The epithelial cells throughout the respiratory tract secrete epithelial lining fluid (ELF), the composition of which is tightly regulated and determines how well mucociliary clearance works.

[18] Pulmonary neuroendocrine cells are found throughout the respiratory epithelium including the alveolar epithelium, [19] though they only account for.

Macrophages exposed to apoptotic cells counteract TGF-β-induced EMT in lung and kidney epithelial cells. TGF-β1 activation is a critical signaling element in EMT and plays a Cited by: Rent or buy Lung Macrophages and Dendritic Cells in Health and Disease - Oncostatin M (OSM), as one of the gp/IL-6 family of cytokines, interacts with receptor complexes that include the gp signaling molecule and OSM receptor β OSMRβ chain subunits.

OSMRβ chains are expressed relatively highly across a broad array of connective tissue (CT) cells of the lung, such as fibroblasts, smooth muscle cells, and epithelial cells, thus enabling robust responses to Author: Carl D.

Richards, Fernando Botelho. ROS generation; co-culture of epithelial cells further enhances this macrophage polarization.

More importantly, macrophage M2 polarization in turn facilitates arsenic-induced transformation of epithelial cells by inhibiting autophagy activity in these cells. Blocking macrophage M2 polarization decreases arsenic-induced by: 4. Basal cells are an abundant population of relatively undifferentiated cells that contact the basement membrane but not the airway lumen.

The expression of characteristic subsets of intermediate filament proteins (keratin 5 [K5], K6, K14, and K16) distinguish basal cells from luminal epithelial by: Comparative Biology of the Normal Lung is the first volume in a series entitled "A Comprehensive Treatise on Pulmonary Toxicology." The book is divided into four sections that deal with morphology and morphometry, respiratory physiology, biochemistry, and pulmonary defense.

A special index lists and cross indexes all comparative data included in the text, which provides readers with easy. Lung epithelial cells (LECs) are strategically positioned in the airway mucosa to provide barrier defense.

LECs also express pattern recognition receptors and a myriad of immune genes, but their role in immunity is often concealed by the activities of “professional” immune Cited by: II epithelial cells at low doses and cell death at higher doses Silica induced activation of pulmonary cells, and the subsequent release of inflammatory mediators and fibrogenic fac- tors, 13 appears to lead to pulmonary fibrosis.

14 As a reflection of this fibrotic response, animalsFile Size: KB. This study reports the correction of pulmonary alveolar proteinosis (PAP) in Csf2rb–/– mice by a single transfer of either wild-type or gene-corrected macrophages directly to the lungs — the.

Idiopathic pulmonary fibrosis (IPF) is a genetic heterogeneous disease with high mortality and poor prognosis. IPF is characterized by persistent fibroblasts and relentless accumulation of collagen matrix. Epithelial-mesenchymal transition (EMT) and endothelial-to-mesenchymal transition (EndoMT) contribute to the progression of the fibrotic : Koichi Takagi, Munekazu Yamakuchi, Teruto Hashiguchi, Hiromasa Inoue.

Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): g (external link)Author: P. Wilkinson. Introduction. Reports of pulmonary malignancies date back as far as antiquity, and by the mid-twentieth century, lung cancer had become epidemic and was firmly established as the leading cause of cancer-related deaths in North America and Europe, following the introduction of cheap, mass-produced cigarettes [].At present, lung cancer is the most common type of cancer worldwide, accounting for.

Airway epithelial cells (AECs) are part of the frontline defense against infection of pathogens by providing both a physical barrier and immunological function. The role of AECs in the innate and adaptive immune responses, through the production of antimicrobial molecules and proinflammatory factors against a variety of pathogens, has been well by: Differences in labeling indices of pulmonary epithelial cells, alveolar macrophages, airway epithelial cells, and cells of the lung-associated lymph nodes between the exposed andmore» Labeling indices for lung epithelial cells were about the same in control and exposed animals at 2.

Prokaryotic (bacterial) cells. All eubacteria have an inner (plasma) membrane which serves as a semipermeable barrier allowing small nonpolar and polar molecules such as oxygen, carbon dioxide, and glycerol to diffuse across (down their concentration gradients), but does not allow the diffusion of larger polar molecules (sugars, amino acids, and so on) or inorganic ions such as Na +, K +, Cl.

Pathology of the lung, Volume 2 epithelial cells epithelium fibres fluid fungus giant cells glands granulomas haematite haemorrhage hyaline membranes hydatid infection inflammatory inhaled interstitial layer lesions liver lobar lower lobes lumen lung abscesses lung damage lung showing lung tissue lymph lymphatic lymphocytes macrophage cells.

CD8 + cells are cytotoxic to epithelial cells through the release of granzymes and perforin, which can further induce apoptosis of alveolar cells.

Moreover, any reduction in neutrophil apoptosis or dysregulation of macrophage uptake of apoptotic neutrophils could lead. Assistant Professor of Medicine Director, Allergy/Immunology Fellowship Training Program Medical Director, Pulmonary, Allergy, and Sleep Clinics.

BU profile for Dr. Little. Education and Training: Undergraduate: Harvard College Medical School: Tufts University School of Medicine Internship: University of California, San Francisco Residency: University of California, San Francisco. InMason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus.

It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the.

Lung epithelial cells are the first line of defense after inhaled stimuli, such as in the case of hyperoxia.

We hypothesized that lung epithelial cells release ‘messenger' or signaling molecules to adjacent or distant macrophages, thereby initiating or propagating inflammatory responses after noxious insult.Macrophage-Epithelial Crosstalk during Alveolar Epithelial Repair following Pathogen-induced Pulmonary Inflammation Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfilment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Lidija Cakarova.Mucociliary clearance involves goblet cells, ciliated epithelial cells and submucosal glands.

6. The large numbers of alveolar macrophages which migrate into lumens of alveoli are derived from/5.